Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4396506..4397125 Replicon chromosome
Accession NZ_OW968280
Organism Klebsiella oxytoca isolate 101

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ191_RS20740 Protein ID WP_004099646.1
Coordinates 4396907..4397125 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ191_RS20735 Protein ID WP_004099648.1
Coordinates 4396506..4396880 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ191_RS20725 (AI2946V1_4056) 4391662..4392855 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ191_RS20730 (AI2946V1_4057) 4392878..4396024 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
LQ191_RS20735 (AI2946V1_4058) 4396506..4396880 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ191_RS20740 (AI2946V1_4059) 4396907..4397125 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ191_RS20745 (AI2946V1_4060) 4397286..4397852 + 567 WP_023320460.1 maltose O-acetyltransferase -
LQ191_RS20750 4397821..4397958 - 138 WP_224226357.1 hypothetical protein -
LQ191_RS20755 (AI2946V1_4061) 4397989..4398459 + 471 WP_004099643.1 YlaC family protein -
LQ191_RS20760 (AI2946V1_4062) 4398434..4399888 - 1455 WP_126488646.1 PLP-dependent aminotransferase family protein -
LQ191_RS20765 (AI2946V1_4063) 4399991..4400689 + 699 WP_004099639.1 GNAT family protein -
LQ191_RS20770 (AI2946V1_4064) 4400686..4400826 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ191_RS20775 (AI2946V1_4065) 4400826..4401089 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T296055 WP_004099646.1 NZ_OW968280:4396907-4397125 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT296055 WP_004099648.1 NZ_OW968280:4396506-4396880 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References