296047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 96623..97266 Replicon plasmid P1
Accession NZ_OW968278
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag LQ166_RS26180 Protein ID WP_001034044.1
Coordinates 96623..97039 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag LQ166_RS26185 Protein ID WP_001261286.1
Coordinates 97036..97266 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS26155 (91726) 91726..92454 - 729 WP_001230787.1 type-F conjugative transfer system secretin TraK -
LQ166_RS26160 (92441) 92441..92971 - 531 WP_001324649.1 type IV conjugative transfer system protein TraE -
LQ166_RS26165 (93036) 93036..93722 + 687 Protein_109 IS1 family transposase -
LQ166_RS26170 (93976) 93976..94998 - 1023 WP_000361402.1 helicase UvrD -
LQ166_RS26175 (94983) 94983..96548 - 1566 WP_001128474.1 AAA family ATPase -
LQ166_RS26180 (96623) 96623..97039 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ166_RS26185 (97036) 97036..97266 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ166_RS26190 (97826) 97826..98044 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
LQ166_RS26195 (98046) 98046..98351 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
LQ166_RS26200 (98352) 98352..99158 + 807 WP_000016970.1 site-specific integrase -
LQ166_RS26205 (99880) 99880..100635 + 756 WP_000852146.1 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-48 / aadA5 / qacE / sul1 / mph(A) / tet(A) - 1..128607 128607


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T296047 WP_001034044.1 NZ_OW968278:c97039-96623 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT296047 WP_001261286.1 NZ_OW968278:c97266-97036 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References