296038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3952980..3953634 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag LQ166_RS19475 Protein ID WP_000244765.1
Coordinates 3953227..3953634 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag LQ166_RS19470 Protein ID WP_000354050.1
Coordinates 3952980..3953246 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS19450 (3949068) 3949068..3950501 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
LQ166_RS19455 (3950546) 3950546..3950857 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
LQ166_RS19460 (3951021) 3951021..3951680 + 660 WP_000250275.1 hemolysin III family protein -
LQ166_RS19465 (3951757) 3951757..3952737 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
LQ166_RS19470 (3952980) 3952980..3953246 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
LQ166_RS19475 (3953227) 3953227..3953634 + 408 WP_000244765.1 protein YgfX Toxin
LQ166_RS19480 (3953674) 3953674..3954195 - 522 WP_001055874.1 flavodoxin FldB -
LQ166_RS19485 (3954307) 3954307..3955203 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ166_RS19490 (3955228) 3955228..3955938 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ166_RS19495 (3955944) 3955944..3957677 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T296038 WP_000244765.1 NZ_OW968277:3953227-3953634 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT296038 WP_000354050.1 NZ_OW968277:3952980-3953246 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References