296034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3290881..3291681 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag LQ166_RS16115 Protein ID WP_000342452.1
Coordinates 3291154..3291681 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LQ166_RS16110 Protein ID WP_001277107.1
Coordinates 3290881..3291147 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS16090 (3286540) 3286540..3287208 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
LQ166_RS16095 (3287201) 3287201..3288259 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
LQ166_RS16100 (3288504) 3288504..3289358 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LQ166_RS16105 (3289629) 3289629..3290732 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ166_RS16110 (3290881) 3290881..3291147 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ166_RS16115 (3291154) 3291154..3291681 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ166_RS16120 (3291678) 3291678..3292061 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ166_RS16125 (3292484) 3292484..3293593 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ166_RS16130 (3293641) 3293641..3294567 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ166_RS16135 (3294564) 3294564..3295841 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
LQ166_RS16140 (3295838) 3295838..3296605 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T296034 WP_000342452.1 NZ_OW968277:3291154-3291681 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT296034 WP_001277107.1 NZ_OW968277:3290881-3291147 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References