Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2475746..2476243 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ166_RS12380 Protein ID WP_001173343.1
Coordinates 2475746..2475919 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag LQ166_RS12385 Protein ID WP_001312331.1
Coordinates 2475947..2476243 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS12370 (2472416) 2472416..2473873 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
LQ166_RS12375 (2474110) 2474110..2475627 + 1518 WP_000003806.1 lysine--tRNA ligase -
LQ166_RS12380 (2475746) 2475746..2475919 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ166_RS12385 (2475947) 2475947..2476243 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ166_RS12390 (2476471) 2476471..2476743 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ166_RS12395 (2476957) 2476957..2480894 - 3938 Protein_2436 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2475746..2491842 16096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T296032 WP_001173343.1 NZ_OW968277:c2475919-2475746 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT296032 WP_001312331.1 NZ_OW968277:c2476243-2475947 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References