296031

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2459640..2460441 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag LQ166_RS12310 Protein ID WP_001094436.1
Coordinates 2460064..2460441 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag LQ166_RS12305 Protein ID WP_015953067.1
Coordinates 2459640..2460017 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS12270 (2455551) 2455551..2456231 + 681 WP_001282919.1 WYL domain-containing protein -
LQ166_RS12275 (2456379) 2456379..2457056 + 678 WP_001097301.1 hypothetical protein -
LQ166_RS12280 (2457062) 2457062..2457295 + 234 WP_001278287.1 DUF905 family protein -
LQ166_RS12285 (2457385) 2457385..2458203 + 819 WP_001175163.1 DUF932 domain-containing protein -
LQ166_RS12290 (2458295) 2458295..2458780 + 486 WP_029700724.1 antirestriction protein -
LQ166_RS12295 (2458795) 2458795..2459271 + 477 WP_001186756.1 RadC family protein -
LQ166_RS12300 (2459340) 2459340..2459561 + 222 WP_000692312.1 DUF987 domain-containing protein -
LQ166_RS12305 (2459640) 2459640..2460017 + 378 WP_015953067.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LQ166_RS12310 (2460064) 2460064..2460441 + 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
LQ166_RS12315 (2460438) 2460438..2460926 + 489 WP_000761714.1 DUF5983 family protein -
LQ166_RS12320 (2460938) 2460938..2461135 + 198 WP_000839254.1 DUF957 domain-containing protein -
LQ166_RS12325 (2461220) 2461220..2461930 + 711 WP_001621817.1 DUF4942 domain-containing protein -
LQ166_RS12330 (2461979) 2461979..2462734 - 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
LQ166_RS12335 (2462731) 2462731..2464230 - 1500 WP_029700729.1 IS21-like element ISEc10 family transposase -
LQ166_RS12340 (2464321) 2464321..2464482 + 162 Protein_2425 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T296031 WP_001094436.1 NZ_OW968277:2460064-2460441 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT296031 WP_015953067.1 NZ_OW968277:2459640-2460017 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References