Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1126718..1127340 Replicon chromosome
Accession NC_021659
Organism Serratia plymuthica S13

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag M621_RS30360 Protein ID WP_006322256.1
Coordinates 1126718..1126921 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag M621_RS30365 Protein ID WP_004949348.1
Coordinates 1126972..1127340 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M621_RS30335 1122485..1122946 + 462 WP_006323963.1 type II secretion system protein M -
M621_RS30340 1122979..1123809 + 831 WP_006323964.1 A24 family peptidase -
M621_RS30345 1123806..1124180 - 375 WP_006323969.1 type II secretion system pilot lipoprotein GspS -
M621_RS30350 1124460..1125881 + 1422 WP_020438550.1 N-acetylglucosamine-binding protein GbpA -
M621_RS30355 1125942..1126478 + 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
M621_RS30360 1126718..1126921 - 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
M621_RS30365 1126972..1127340 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
M621_RS30370 1127500..1127853 - 354 WP_004949349.1 hypothetical protein -
M621_RS30380 1128305..1129018 + 714 WP_006323974.1 ABC transporter ATP-binding protein -
M621_RS30385 1129015..1129872 + 858 WP_004949351.1 metal ABC transporter permease -
M621_RS30390 1129898..1130776 + 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
M621_RS30395 1130891..1131031 - 141 WP_004949353.1 type B 50S ribosomal protein L36 -
M621_RS30400 1131044..1131298 - 255 WP_004949355.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T29603 WP_006322256.1 NC_021659:c1126921-1126718 [Serratia plymuthica S13]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T29603 NC_021659:c1126921-1126718 [Serratia plymuthica S13]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT29603 WP_004949348.1 NC_021659:c1127340-1126972 [Serratia plymuthica S13]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT29603 NC_021659:c1127340-1126972 [Serratia plymuthica S13]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References