Detailed information of TA system TA296026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1698602..1700291
• Replicon: chromosome
• Accession: NZ_OW968277
• Organism: Escherichia coli isolate 131

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: LQ166_RS08560
• Protein ID: WP_000365807.1
• Coordinates: 1698602..1699522 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LQ166_RS08565
• Protein ID: WP_001295795.1
• Coordinates: 1699509..1700291 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ166_RS08520 (1694075)	1694075..1694785	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
LQ166_RS08525 (1695092)	1695092..1695421	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
LQ166_RS08530 (1695433)	1695433..1695599	-	167	Protein_1678	tail fiber assembly protein	-
LQ166_RS08535 (1695670)	1695670..1696284	-	615	WP_001019923.1	YagU family protein	-
LQ166_RS08540 (1696499)	1696499..1696684	-	186	WP_000146240.1	hypothetical protein	-
LQ166_RS08545 (1696733)	1696733..1696891	+	159	Protein_1681	integrase	-
LQ166_RS08550 (1697118)	1697118..1697453	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
LQ166_RS08555 (1697661)	1697661..1698437	+	777	WP_000171155.1	site-specific integrase	-
LQ166_RS08560 (1698602)	1698602..1699522	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQ166_RS08565 (1699509)	1699509..1700291	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
LQ166_RS08570 (1700575)	1700575..1703673	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	1658386..1707354	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T296026 WP_000365807.1 NZ_OW968277:c1699522-1698602 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT296026 WP_001295795.1 NZ_OW968277:c1700291-1699509 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0