Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1515295..1515913 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ166_RS07695 Protein ID WP_001291435.1
Coordinates 1515695..1515913 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ166_RS07690 Protein ID WP_000344800.1
Coordinates 1515295..1515669 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS07680 (1510384) 1510384..1511577 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ166_RS07685 (1511600) 1511600..1514749 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
LQ166_RS07690 (1515295) 1515295..1515669 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ166_RS07695 (1515695) 1515695..1515913 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ166_RS07700 (1516087) 1516087..1516638 + 552 WP_000102539.1 maltose O-acetyltransferase -
LQ166_RS07705 (1516754) 1516754..1517224 + 471 WP_000136192.1 YlaC family protein -
LQ166_RS07710 (1517388) 1517388..1518938 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ166_RS07715 (1518980) 1518980..1519333 - 354 WP_000878135.1 DUF1428 family protein -
LQ166_RS07725 (1519712) 1519712..1520023 + 312 WP_000409908.1 MGMT family protein -
LQ166_RS07730 (1520054) 1520054..1520626 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296025 WP_001291435.1 NZ_OW968277:1515695-1515913 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT296025 WP_000344800.1 NZ_OW968277:1515295-1515669 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References