29602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 483255..484878 Replicon chromosome
Accession NC_021659
Organism Serratia plymuthica S13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M621_RS27390 Protein ID WP_041417521.1
Coordinates 483556..484878 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID S4YPP9
Locus tag M621_RS27385 Protein ID WP_020438366.1
Coordinates 483255..483551 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M621_RS51370 479174..479452 - 279 WP_144080223.1 hypothetical protein -
M621_RS27365 480162..480299 + 138 WP_100220743.1 type II toxin-antitoxin system RelE/ParE family toxin -
M621_RS27370 480283..480605 + 323 Protein_423 DNA-binding transcriptional regulator -
M621_RS27375 480918..481478 - 561 WP_006323369.1 hypothetical protein -
M621_RS27380 482412..483047 + 636 WP_020438365.1 carbonic anhydrase -
M621_RS27385 483255..483551 + 297 WP_020438366.1 helix-turn-helix transcriptional regulator Antitoxin
M621_RS27390 483556..484878 + 1323 WP_041417521.1 type II toxin-antitoxin system HipA family toxin Toxin
M621_RS27395 484934..486193 - 1260 WP_020438368.1 GIY-YIG nuclease family protein -
M621_RS27400 486195..488201 - 2007 WP_020438369.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49907.03 Da        Isoelectric Point: 6.8707

>T29602 WP_041417521.1 NC_021659:483556-484878 [Serratia plymuthica S13]
MRRSQQRLAIWMNSIPVGYWEKRKGEDRLEYLPGWIADNQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRFHAESLDPFDLLTELGRDCVGAIQLLDIDEQPTHIFSIRQRPLSEAQIAEMLRNTATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNRWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDGQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRRFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDLVAGLLPDSFSPELAACIFDGIRQQCARLKGR

Download         Length: 1323 bp

>T29602 NC_021659:483556-484878 [Serratia plymuthica S13]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATAGTATTCCGGTGGGATACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGGTTGGATTGCAGATAACCAGGGGAGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ACCAGCCTTATCGCGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTTTCATGCCGAAAGCCTTGATCCTTTTGATTTACTGACTGAACTGGGCCGCGACTGTGTGGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCACTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGCGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCGGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGCCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCGCTTTTTTAAGGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAAGTTGAATCCATTATTGAAGAGCTGCTG
GCGGCAACCCCGGGAGTTATTGATCTGGTCGCTGGCCTGCTGCCTGATTCGTTTTCGCCTGAATTAGCGGCATGTATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGCTGAAAGGGAGATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10965.46 Da        Isoelectric Point: 8.0099

>AT29602 WP_020438366.1 NC_021659:483255-483551 [Serratia plymuthica S13]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEVVLSSELTSPGCE
TEDTSTTHIDSPARREQW

Download         Length: 297 bp

>AT29602 NC_021659:483255-483551 [Serratia plymuthica S13]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAATTACGCCCTTTGCTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAGAGGCTGGGCGTCACCCAGCAGACCTACGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATGTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGGCGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4YPP9

References