Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4411711..4412208 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ159_RS21525 Protein ID WP_001173343.1
Coordinates 4411711..4411884 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ159_RS21530 Protein ID WP_000398619.1
Coordinates 4411912..4412208 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS21515 (4408381) 4408381..4409838 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
LQ159_RS21520 (4410075) 4410075..4411592 + 1518 WP_001295074.1 lysine--tRNA ligase -
LQ159_RS21525 (4411711) 4411711..4411884 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ159_RS21530 (4411912) 4411912..4412208 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ159_RS21535 (4412435) 4412435..4412707 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
LQ159_RS21540 (4412719) 4412719..4412949 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
LQ159_RS21545 (4413130) 4413130..4414761 + 1632 WP_001216477.1 sensor histidine kinase -
LQ159_RS21550 (4414758) 4414758..4415477 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T296004 WP_001173343.1 NZ_OW968124:c4411884-4411711 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT296004 WP_000398619.1 NZ_OW968124:c4412208-4411912 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References