Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 4925897..4926462 Replicon chromosome
Accession NC_021591
Organism Serratia plymuthica 4Rx13

Toxin (Protein)


Gene name relE Uniprot ID A0A318NZU8
Locus tag SOD_RS22500 Protein ID WP_041417217.1
Coordinates 4926184..4926462 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag SOD_RS22495 Protein ID WP_004951261.1
Coordinates 4925897..4926166 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SOD_RS22480 4922112..4923329 - 1218 WP_004951256.1 aspartate aminotransferase family protein -
SOD_RS22485 4923460..4924035 - 576 WP_006328493.1 aminodeoxychorismate synthase component II -
SOD_RS22490 4924141..4925667 - 1527 WP_004951259.1 DUF853 family protein -
SOD_RS22495 4925897..4926166 + 270 WP_004951261.1 hypothetical protein Antitoxin
SOD_RS22500 4926184..4926462 + 279 WP_041417217.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SOD_RS22505 4926463..4927188 - 726 WP_004951264.1 two-component system response regulator BtsR -
SOD_RS22510 4927188..4928873 - 1686 WP_004951267.1 sensor histidine kinase -
SOD_RS22515 4929033..4929602 - 570 WP_004951269.1 peptidylprolyl isomerase A -
SOD_RS22520 4929958..4930296 + 339 WP_004951271.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10230.84 Da        Isoelectric Point: 8.5141

>T29600 WP_041417217.1 NC_021591:4926184-4926462 [Serratia plymuthica 4Rx13]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T29600 NC_021591:4926184-4926462 [Serratia plymuthica 4Rx13]
GTGACACTCAAGTGGACGGAACCCGCGATTGCCGATCGTATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAGCTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT29600 WP_004951261.1 NC_021591:4925897-4926166 [Serratia plymuthica 4Rx13]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT29600 NC_021591:4925897-4926166 [Serratia plymuthica 4Rx13]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCGGCCAAAGCAGCCGATCG
CACAGCATCTCAGTTGCTGCGTGATTTCATGCGTGATTTTGTCAGTCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTGAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAGCGCAGGTCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318NZU8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References