Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545636..3546254 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ159_RS17245 Protein ID WP_001291435.1
Coordinates 3546036..3546254 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ159_RS17240 Protein ID WP_000344800.1
Coordinates 3545636..3546010 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS17230 (3540725) 3540725..3541918 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ159_RS17235 (3541941) 3541941..3545090 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ159_RS17240 (3545636) 3545636..3546010 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ159_RS17245 (3546036) 3546036..3546254 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ159_RS17250 (3546426) 3546426..3546977 + 552 WP_000102564.1 maltose O-acetyltransferase -
LQ159_RS17255 (3547093) 3547093..3547563 + 471 WP_000136192.1 YlaC family protein -
LQ159_RS17260 (3547727) 3547727..3549277 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ159_RS17265 (3549319) 3549319..3549672 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ159_RS17275 (3550051) 3550051..3550362 + 312 WP_000409911.1 MGMT family protein -
LQ159_RS17280 (3550393) 3550393..3550965 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295999 WP_001291435.1 NZ_OW968124:3546036-3546254 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295999 WP_000344800.1 NZ_OW968124:3545636-3546010 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References