Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2507597..2508235 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LQ159_RS12205 Protein ID WP_001447010.1
Coordinates 2508059..2508235 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ159_RS12200 Protein ID WP_001270286.1
Coordinates 2507597..2508013 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS12180 (2502749) 2502749..2503690 - 942 WP_001251304.1 ABC transporter permease -
LQ159_RS12185 (2503691) 2503691..2504704 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LQ159_RS12190 (2504722) 2504722..2505867 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LQ159_RS12195 (2506112) 2506112..2507518 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LQ159_RS12200 (2507597) 2507597..2508013 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ159_RS12205 (2508059) 2508059..2508235 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ159_RS12210 (2508457) 2508457..2508687 + 231 WP_000494244.1 YncJ family protein -
LQ159_RS12215 (2508779) 2508779..2510740 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ159_RS12220 (2510813) 2510813..2511349 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LQ159_RS12225 (2511441) 2511441..2512616 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T295998 WP_001447010.1 NZ_OW968124:c2508235-2508059 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT295998 WP_001270286.1 NZ_OW968124:c2508013-2507597 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References