Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 859344..859998 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LQ159_RS04185 Protein ID WP_000244777.1
Coordinates 859591..859998 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ159_RS04180 Protein ID WP_000354046.1
Coordinates 859344..859610 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS04155 (854513) 854513..855256 + 744 WP_000951964.1 SDR family oxidoreductase -
LQ159_RS04160 (855313) 855313..856746 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
LQ159_RS04165 (856791) 856791..857102 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LQ159_RS04170 (857266) 857266..857925 + 660 WP_000250274.1 hemolysin III family protein -
LQ159_RS04175 (858121) 858121..859101 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LQ159_RS04180 (859344) 859344..859610 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ159_RS04185 (859591) 859591..859998 + 408 WP_000244777.1 protein YgfX Toxin
LQ159_RS04190 (860038) 860038..860559 - 522 WP_001055874.1 flavodoxin FldB -
LQ159_RS04195 (860671) 860671..861567 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ159_RS04200 (861592) 861592..862302 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ159_RS04205 (862308) 862308..864041 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T295989 WP_000244777.1 NZ_OW968124:859591-859998 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295989 WP_000354046.1 NZ_OW968124:859344-859610 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References