Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4344156..4344825 Replicon chromosome
Accession NC_021591
Organism Serratia plymuthica 4Rx13

Toxin (Protein)


Gene name cptA Uniprot ID A0A318NST4
Locus tag SOD_RS19760 Protein ID WP_004952425.1
Coordinates 4344156..4344578 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S4YS10
Locus tag SOD_RS19765 Protein ID WP_004952428.1
Coordinates 4344559..4344825 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SOD_RS19740 4340041..4340559 + 519 WP_004952413.1 flavodoxin FldB -
SOD_RS19745 4340597..4341961 - 1365 WP_004952415.1 cell envelope integrity protein CreD -
SOD_RS19750 4342046..4343464 - 1419 WP_004952417.1 two-component system sensor histidine kinase CreC -
SOD_RS19755 4343461..4344156 - 696 WP_004952420.1 two-component system response regulator CreB -
SOD_RS19760 4344156..4344578 - 423 WP_004952425.1 protein YgfX Toxin
SOD_RS19765 4344559..4344825 - 267 WP_004952428.1 FAD assembly factor SdhE Antitoxin
SOD_RS19770 4345150..4346136 + 987 WP_004952431.1 tRNA-modifying protein YgfZ -
SOD_RS19775 4346190..4346687 - 498 WP_004952434.1 DUF2165 domain-containing protein -
SOD_RS19780 4346851..4347528 - 678 WP_004952439.1 hemolysin III family protein -
SOD_RS19785 4347719..4348327 + 609 WP_004952444.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16445.41 Da        Isoelectric Point: 11.2266

>T29598 WP_004952425.1 NC_021591:c4344578-4344156 [Serratia plymuthica 4Rx13]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRFGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Download         Length: 423 bp

>T29598 NC_021591:c4344578-4344156 [Serratia plymuthica 4Rx13]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAACGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTTCGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTGTGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGTTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10446.90 Da        Isoelectric Point: 5.0843

>AT29598 WP_004952428.1 NC_021591:c4344825-4344559 [Serratia plymuthica 4Rx13]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT29598 NC_021591:c4344825-4344559 [Serratia plymuthica 4Rx13]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318NST4

Antitoxin

Source ID Structure
AlphaFold DB S4YS10

References