Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 111496..112121 Replicon plasmid P1
Accession NZ_OW968112
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ120_RS23710 Protein ID WP_000911313.1
Coordinates 111496..111894 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag LQ120_RS23715 Protein ID WP_000450520.1
Coordinates 111894..112121 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS23690 (106780) 106780..107805 + 1026 Protein_113 conjugal transfer protein TraG -
LQ120_RS23695 (107821) 107821..108318 + 498 WP_000605857.1 entry exclusion protein -
LQ120_RS23700 (108350) 108350..109081 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
LQ120_RS23705 (109334) 109334..111487 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
LQ120_RS23710 (111496) 111496..111894 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ120_RS23715 (111894) 111894..112121 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxA / oqxB / catA1 / tet(B) / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..160357 160357
- flank IS/Tn - - 105465..106673 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T295979 WP_000911313.1 NZ_OW968112:c111894-111496 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT295979 WP_000450520.1 NZ_OW968112:c112121-111894 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References