Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4304538..4305035 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ120_RS20925 Protein ID WP_001173343.1
Coordinates 4304538..4304711 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ120_RS20930 Protein ID WP_000398619.1
Coordinates 4304739..4305035 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS20915 (4301208) 4301208..4302665 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
LQ120_RS20920 (4302902) 4302902..4304419 + 1518 WP_001295087.1 lysine--tRNA ligase -
LQ120_RS20925 (4304538) 4304538..4304711 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ120_RS20930 (4304739) 4304739..4305035 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ120_RS20935 (4305262) 4305262..4305534 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
LQ120_RS20940 (4305546) 4305546..4305776 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
LQ120_RS20945 (4305957) 4305957..4307588 + 1632 WP_001216487.1 sensor histidine kinase -
LQ120_RS20950 (4307585) 4307585..4308304 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295977 WP_001173343.1 NZ_OW968111:c4304711-4304538 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT295977 WP_000398619.1 NZ_OW968111:c4305035-4304739 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References