Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3521316..3522153 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag LQ120_RS17130 Protein ID WP_000227784.1
Coordinates 3521611..3522153 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag LQ120_RS17125 Protein ID WP_001297137.1
Coordinates 3521316..3521627 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS17100 (3516336) 3516336..3517283 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
LQ120_RS17105 (3517305) 3517305..3519296 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
LQ120_RS17110 (3519286) 3519286..3519900 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
LQ120_RS17115 (3519900) 3519900..3520229 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
LQ120_RS17120 (3520241) 3520241..3521131 + 891 WP_000971336.1 heme o synthase -
LQ120_RS17125 (3521316) 3521316..3521627 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
LQ120_RS17130 (3521611) 3521611..3522153 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
LQ120_RS17135 (3522209) 3522209..3523144 - 936 WP_001368479.1 tetratricopeptide repeat protein -
LQ120_RS17140 (3523552) 3523552..3524916 + 1365 WP_001000960.1 MFS transporter -
LQ120_RS17145 (3525044) 3525044..3525535 - 492 WP_001138904.1 nucleotide binding protein YajQ -
LQ120_RS17150 (3525703) 3525703..3526614 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T295975 WP_000227784.1 NZ_OW968111:3521611-3522153 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT295975 WP_001297137.1 NZ_OW968111:3521316-3521627 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References