Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3487239..3487857 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ120_RS16960 Protein ID WP_001291435.1
Coordinates 3487639..3487857 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ120_RS16955 Protein ID WP_000344800.1
Coordinates 3487239..3487613 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS16945 (3482328) 3482328..3483521 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ120_RS16950 (3483544) 3483544..3486693 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ120_RS16955 (3487239) 3487239..3487613 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ120_RS16960 (3487639) 3487639..3487857 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ120_RS16965 (3488029) 3488029..3488580 + 552 WP_000102564.1 maltose O-acetyltransferase -
LQ120_RS16970 (3488696) 3488696..3489166 + 471 WP_000136192.1 YlaC family protein -
LQ120_RS16975 (3489330) 3489330..3490880 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ120_RS16980 (3490922) 3490922..3491275 - 354 WP_000878141.1 DUF1428 family protein -
LQ120_RS16990 (3491654) 3491654..3491965 + 312 WP_000409911.1 MGMT family protein -
LQ120_RS16995 (3491996) 3491996..3492568 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295974 WP_001291435.1 NZ_OW968111:3487639-3487857 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295974 WP_000344800.1 NZ_OW968111:3487239-3487613 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References