Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2364778..2365874 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name hipA Uniprot ID A0A8S7TJ53
Locus tag LQ120_RS11550 Protein ID WP_063112742.1
Coordinates 2365044..2365874 (+) Length 277 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQ120_RS11545 Protein ID WP_001296726.1
Coordinates 2364778..2365044 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS11545 (2364778) 2364778..2365044 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQ120_RS11550 (2365044) 2365044..2365874 + 831 WP_063112742.1 HipA N-terminal domain-containing protein Toxin
LQ120_RS11555 (2366186) 2366186..2366394 + 209 Protein_2265 AraC family transcriptional regulator -
LQ120_RS11560 (2366826) 2366826..2367389 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
LQ120_RS11565 (2367749) 2367749..2368459 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -
LQ120_RS11570 (2368501) 2368501..2370807 + 2307 Protein_2268 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2364778..2381150 16372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(115-237)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 277 a.a.        Molecular weight: 31181.99 Da        Isoelectric Point: 10.0235

>T295973 WP_063112742.1 NZ_OW968111:2365044-2365874 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 831 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT295973 WP_001296726.1 NZ_OW968111:2364778-2365044 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References