Detailed information of TA system TA029597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3097703..3098271
• Replicon: chromosome
• Accession: NC_021591
• Organism: Serratia plymuthica 4Rx13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SOD_RS25220
• Protein ID: WP_071824726.1
• Coordinates: 3097703..3097828 (+)
• Length: 42 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A318PA30
• Locus tag: SOD_RS14085
• Protein ID: WP_004945931.1
• Coordinates: 3097858..3098271 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SOD_RS25770	3093144..3093404	-	261	WP_147150478.1	hypothetical protein	-
SOD_RS14080	3093507..3097478	+	3972	WP_004945922.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
SOD_RS25220	3097703..3097828	+	126	WP_071824726.1	type II toxin-antitoxin system HicA family toxin	Toxin
SOD_RS14085	3097858..3098271	+	414	WP_004945931.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SOD_RS14090	3098304..3099056	-	753	WP_004945934.1	L-cystine ABC transporter ATP-binding protein YecC	-
SOD_RS14095	3099060..3099722	-	663	WP_004945937.1	cystine ABC transporter permease	-
SOD_RS14100	3099722..3100521	-	800	Protein_2792	cystine ABC transporter substrate-binding protein	-
SOD_RS14105	3100635..3101627	-	993	WP_004945944.1	D-cysteine desulfhydrase	-
SOD_RS14110	3101753..3102262	-	510	WP_004945946.1	flagella biosynthesis regulatory protein FliZ	-
SOD_RS14115	3102319..3103041	-	723	WP_004945948.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-40)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4628.49 Da
• Isoelectric Point: 11.3100

>T29597 WP_071824726.1 NC_021591:3097703-3097828 [Serratia plymuthica 4Rx13]
IKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 126 bp

>T29597 NC_021591:3097703-3097828 [Serratia plymuthica 4Rx13]
ATAAAGGGAAGCCACCATCAGTTCAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCCCACCCGCGTAAAGATCTGAA
GCCGGGAACGCTGCGCCAAATCATGAAAGATGCCGGGCTGTGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15197.94 Da
• Isoelectric Point: 4.6961

>AT29597 WP_004945931.1 NC_021591:3097858-3098271 [Serratia plymuthica 4Rx13]
MFYPVYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFNGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVD

Nucleotide

• Length: 414 bp

>AT29597 NC_021591:3097858-3098271 [Serratia plymuthica 4Rx13]
ATGTTCTACCCTGTTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCAATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCCGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTGT
TGAAAGTCGATTAG

Structures

Antitoxin

• AlphaFold DB: A0A318PA30