Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3097703..3098271 Replicon chromosome
Accession NC_021591
Organism Serratia plymuthica 4Rx13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SOD_RS25220 Protein ID WP_071824726.1
Coordinates 3097703..3097828 (+) Length 42 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A318PA30
Locus tag SOD_RS14085 Protein ID WP_004945931.1
Coordinates 3097858..3098271 (+) Length 138 a.a.

Genomic Context

SOD_RS14080SOD_RS25220SOD_RS14085SOD_RS25770SOD_RS14090SOD_RS14095SOD_RS14100SOD_RS14105SOD_RS14110SOD_RS14115
Location: 3093507..3097478 (3972 bp)
Type: Others
Protein ID: WP_004945922.1
Location: 3097703..3097828 (126 bp)
Type: Toxin
Protein ID: WP_071824726.1
Location: 3097858..3098271 (414 bp)
Type: Antitoxin
Protein ID: WP_004945931.1
Location: 3093144..3093404 (261 bp)
Type: Others
Protein ID: WP_147150478.1
Location: 3098304..3099056 (753 bp)
Type: Others
Protein ID: WP_004945934.1
Location: 3099060..3099722 (663 bp)
Type: Others
Protein ID: WP_004945937.1
Location: 3099722..3100521 (800 bp)
Type: Others
Protein ID: Protein_2792
Location: 3100635..3101627 (993 bp)
Type: Others
Protein ID: WP_004945944.1
Location: 3101753..3102262 (510 bp)
Type: Others
Protein ID: WP_004945946.1
Location: 3102319..3103041 (723 bp)
Type: Others
Protein ID: WP_004945948.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SOD_RS257703093144..3093404-261WP_147150478.1hypothetical protein-
SOD_RS140803093507..3097478+3972WP_004945922.1trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase-
SOD_RS252203097703..3097828+126WP_071824726.1type II toxin-antitoxin system HicA family toxinToxin
SOD_RS140853097858..3098271+414WP_004945931.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
SOD_RS140903098304..3099056-753WP_004945934.1L-cystine ABC transporter ATP-binding protein YecC-
SOD_RS140953099060..3099722-663WP_004945937.1cystine ABC transporter permease-
SOD_RS141003099722..3100521-800Protein_2792cystine ABC transporter substrate-binding protein-
SOD_RS141053100635..3101627-993WP_004945944.1D-cysteine desulfhydrase-
SOD_RS141103101753..3102262-510WP_004945946.1flagella biosynthesis regulatory protein FliZ-
SOD_RS141153102319..3103041-723WP_004945948.1RNA polymerase sigma factor FliA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-40)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4628.49 Da        Isoelectric Point: 11.3100

>T29597 WP_071824726.1 NC_021591:3097703-3097828 [Serratia plymuthica 4Rx13]
IKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 126 bp

>T29597 NC_021591:3097703-3097828 [Serratia plymuthica 4Rx13]
ATAAAGGGAAGCCACCATCAGTTCAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCCCACCCGCGTAAAGATCTGAA
GCCGGGAACGCTGCGCCAAATCATGAAAGATGCCGGGCTGTGCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15197.94 Da        Isoelectric Point: 4.6961

>AT29597 WP_004945931.1 NC_021591:3097858-3098271 [Serratia plymuthica 4Rx13]
MFYPVYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFNGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVD

Download         Length: 414 bp

>AT29597 NC_021591:3097858-3098271 [Serratia plymuthica 4Rx13]
ATGTTCTACCCTGTTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCAATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCCGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTGT
TGAAAGTCGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A318PA30

References