Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1328220..1328845 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ120_RS06410 Protein ID WP_000911330.1
Coordinates 1328447..1328845 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LQ120_RS06405 Protein ID WP_000450524.1
Coordinates 1328220..1328447 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS06380 (1324023) 1324023..1324493 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LQ120_RS06385 (1324493) 1324493..1325065 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LQ120_RS06390 (1325211) 1325211..1326089 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LQ120_RS06395 (1326106) 1326106..1327140 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
LQ120_RS06400 (1327353) 1327353..1328066 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LQ120_RS06405 (1328220) 1328220..1328447 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LQ120_RS06410 (1328447) 1328447..1328845 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ120_RS06415 (1328992) 1328992..1329855 + 864 WP_001267498.1 neutral zinc metallopeptidase -
LQ120_RS06420 (1329870) 1329870..1331885 + 2016 WP_063112794.1 tRNA cytosine(34) acetyltransferase TmcA -
LQ120_RS06425 (1331959) 1331959..1332657 + 699 WP_000679823.1 esterase -
LQ120_RS06430 (1332767) 1332767..1332967 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T295967 WP_000911330.1 NZ_OW968111:1328447-1328845 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT295967 WP_000450524.1 NZ_OW968111:1328220-1328447 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References