Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 893826..894480 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LQ120_RS04345 Protein ID WP_063112724.1
Coordinates 894073..894480 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ120_RS04340 Protein ID WP_000354046.1
Coordinates 893826..894092 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS04315 (889114) 889114..889857 + 744 WP_000951964.1 SDR family oxidoreductase -
LQ120_RS04320 (889914) 889914..891347 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
LQ120_RS04325 (891392) 891392..891703 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
LQ120_RS04330 (891867) 891867..892526 + 660 WP_000250274.1 hemolysin III family protein -
LQ120_RS04335 (892603) 892603..893583 - 981 WP_001472148.1 tRNA-modifying protein YgfZ -
LQ120_RS04340 (893826) 893826..894092 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ120_RS04345 (894073) 894073..894480 + 408 WP_063112724.1 protein YgfX Toxin
LQ120_RS04350 (894520) 894520..895041 - 522 WP_001055874.1 flavodoxin FldB -
LQ120_RS04355 (895153) 895153..896049 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ120_RS04360 (896074) 896074..896784 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ120_RS04365 (896790) 896790..898523 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16082.04 Da        Isoelectric Point: 11.2511

>T295965 WP_063112724.1 NZ_OW968111:894073-894480 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLFHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295965 WP_000354046.1 NZ_OW968111:893826-894092 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References