Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 268994..269625 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag LQ120_RS01210 Protein ID WP_001259388.1
Coordinates 268994..269269 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LQ120_RS01215 Protein ID WP_000593555.1
Coordinates 269266..269625 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS01195 (263998) 263998..265065 + 1068 WP_000361485.1 HlyD family secretion protein -
LQ120_RS01200 (265062) 265062..267797 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
LQ120_RS01205 (267797) 267797..268921 + 1125 WP_001314210.1 ABC transporter permease -
LQ120_RS01210 (268994) 268994..269269 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ120_RS01215 (269266) 269266..269625 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ120_RS01220 (269745) 269745..270146 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LQ120_RS01225 (270152) 270152..270958 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LQ120_RS01230 (270955) 270955..271719 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LQ120_RS01235 (271719) 271719..272552 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
LQ120_RS01240 (272549) 272549..273493 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 261395..269625 8230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T295962 WP_001259388.1 NZ_OW968111:268994-269269 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT295962 WP_000593555.1 NZ_OW968111:269266-269625 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References