Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4224640..4225258 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ149_RS20170 Protein ID WP_001291435.1
Coordinates 4224640..4224858 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ149_RS20175 Protein ID WP_000344800.1
Coordinates 4224884..4225258 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS20130 (4219756) 4219756..4220067 - 312 WP_000409911.1 MGMT family protein -
LQ149_RS20140 (4220446) 4220446..4220799 + 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ149_RS20145 (4220841) 4220841..4221107 - 267 Protein_3932 EAL domain-containing protein -
LQ149_RS20150 (4221163) 4221163..4221860 + 698 WP_223429336.1 IS1 family transposase -
LQ149_RS20155 (4221875) 4221875..4223167 - 1293 Protein_3934 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ149_RS20160 (4223331) 4223331..4223801 - 471 WP_000136192.1 YlaC family protein -
LQ149_RS20165 (4223917) 4223917..4224468 - 552 WP_000102568.1 maltose O-acetyltransferase -
LQ149_RS20170 (4224640) 4224640..4224858 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ149_RS20175 (4224884) 4224884..4225258 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ149_RS20180 (4225804) 4225804..4228953 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ149_RS20185 (4228976) 4228976..4230169 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295959 WP_001291435.1 NZ_OW968011:c4224858-4224640 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295959 WP_000344800.1 NZ_OW968011:c4225258-4224884 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References