Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3533639..3534234 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ149_RS16930 Protein ID WP_000239579.1
Coordinates 3533884..3534234 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LQ149_RS16925 Protein ID WP_001223208.1
Coordinates 3533639..3533890 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS16915 (3529303) 3529303..3533082 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
LQ149_RS16920 (3533085) 3533085..3533426 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ149_RS16925 (3533639) 3533639..3533890 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ149_RS16930 (3533884) 3533884..3534234 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ149_RS16935 (3534314) 3534314..3534844 - 531 WP_000055072.1 inorganic diphosphatase -
LQ149_RS16940 (3535154) 3535154..3536110 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ149_RS16945 (3536420) 3536420..3537922 + 1503 WP_021548597.1 sugar ABC transporter ATP-binding protein -
LQ149_RS16950 (3537936) 3537936..3538958 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T295956 WP_000239579.1 NZ_OW968011:3533884-3534234 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT295956 WP_001223208.1 NZ_OW968011:3533639-3533890 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References