Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2668558..2669144 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag LQ149_RS12930 Protein ID WP_042014162.1
Coordinates 2668914..2669144 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LQ149_RS12925 Protein ID WP_000593555.1
Coordinates 2668558..2668917 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS12900 (2664690) 2664690..2665634 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
LQ149_RS12905 (2665631) 2665631..2666464 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
LQ149_RS12910 (2666464) 2666464..2667228 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LQ149_RS12915 (2667225) 2667225..2668031 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LQ149_RS12920 (2668037) 2668037..2668438 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LQ149_RS12925 (2668558) 2668558..2668917 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ149_RS12930 (2668914) 2668914..2669144 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ149_RS12935 (2669248) 2669248..2670372 - 1125 WP_001314210.1 ABC transporter permease -
LQ149_RS12940 (2670372) 2670372..2673107 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T295953 WP_042014162.1 NZ_OW968011:c2669144-2668914 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT295953 WP_000593555.1 NZ_OW968011:c2668917-2668558 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References