295952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2647051..2647851 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag LQ149_RS12805 Protein ID WP_000342449.1
Coordinates 2647051..2647578 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag LQ149_RS12810 Protein ID WP_001277108.1
Coordinates 2647585..2647851 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS12780 (2642126) 2642126..2642893 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LQ149_RS12785 (2642890) 2642890..2644167 - 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
LQ149_RS12790 (2644164) 2644164..2645090 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ149_RS12795 (2645138) 2645138..2646247 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ149_RS12800 (2646671) 2646671..2647054 + 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ149_RS12805 (2647051) 2647051..2647578 - 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ149_RS12810 (2647585) 2647585..2647851 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ149_RS12815 (2648001) 2648001..2649104 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ149_RS12820 (2649375) 2649375..2650229 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LQ149_RS12825 (2650474) 2650474..2651532 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
LQ149_RS12830 (2651525) 2651525..2652193 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T295952 WP_000342449.1 NZ_OW968011:c2647578-2647051 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT295952 WP_001277108.1 NZ_OW968011:c2647851-2647585 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References