Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2073209..2073863 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag LQ149_RS09920 Protein ID WP_000244772.1
Coordinates 2073209..2073616 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ149_RS09925 Protein ID WP_000354046.1
Coordinates 2073597..2073863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS09900 (2069166) 2069166..2070899 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
LQ149_RS09905 (2070905) 2070905..2071615 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ149_RS09910 (2071640) 2071640..2072536 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ149_RS09915 (2072648) 2072648..2073169 + 522 WP_001055874.1 flavodoxin FldB -
LQ149_RS09920 (2073209) 2073209..2073616 - 408 WP_000244772.1 protein YgfX Toxin
LQ149_RS09925 (2073597) 2073597..2073863 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ149_RS09930 (2074106) 2074106..2075086 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LQ149_RS09935 (2075163) 2075163..2075822 - 660 WP_000250274.1 hemolysin III family protein -
LQ149_RS09940 (2075986) 2075986..2076297 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
LQ149_RS09945 (2076342) 2076342..2077775 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
LQ149_RS09950 (2077832) 2077832..2078575 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T295950 WP_000244772.1 NZ_OW968011:c2073616-2073209 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295950 WP_000354046.1 NZ_OW968011:c2073863-2073597 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References