Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1628479..1629104 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ149_RS07785 Protein ID WP_000911330.1
Coordinates 1628479..1628877 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LQ149_RS07790 Protein ID WP_000450524.1
Coordinates 1628877..1629104 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS07765 (1624357) 1624357..1624557 + 201 WP_000383836.1 YpfN family protein -
LQ149_RS07770 (1624667) 1624667..1625365 - 699 WP_000679823.1 esterase -
LQ149_RS07775 (1625439) 1625439..1627454 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
LQ149_RS07780 (1627469) 1627469..1628332 - 864 WP_001267508.1 neutral zinc metallopeptidase -
LQ149_RS07785 (1628479) 1628479..1628877 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ149_RS07790 (1628877) 1628877..1629104 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LQ149_RS07795 (1629258) 1629258..1629971 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LQ149_RS07800 (1630184) 1630184..1631218 - 1035 WP_128573118.1 outer membrane protein assembly factor BamC -
LQ149_RS07805 (1631235) 1631235..1632113 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LQ149_RS07810 (1632259) 1632259..1632831 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LQ149_RS07815 (1632831) 1632831..1633301 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T295948 WP_000911330.1 NZ_OW968011:c1628877-1628479 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT295948 WP_000450524.1 NZ_OW968011:c1629104-1628877 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References