Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4403844..4404341 Replicon chromosome
Accession NZ_OW967975
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ150_RS21465 Protein ID WP_001173343.1
Coordinates 4403844..4404017 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ150_RS21470 Protein ID WP_000398619.1
Coordinates 4404045..4404341 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ150_RS21455 (4400514) 4400514..4401971 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
LQ150_RS21460 (4402208) 4402208..4403725 + 1518 WP_001295074.1 lysine--tRNA ligase -
LQ150_RS21465 (4403844) 4403844..4404017 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ150_RS21470 (4404045) 4404045..4404341 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ150_RS21475 (4404568) 4404568..4404840 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
LQ150_RS21480 (4404852) 4404852..4405082 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
LQ150_RS21485 (4405263) 4405263..4406894 + 1632 WP_001216477.1 sensor histidine kinase -
LQ150_RS21490 (4406891) 4406891..4407610 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295919 WP_001173343.1 NZ_OW967975:c4404017-4403844 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT295919 WP_000398619.1 NZ_OW967975:c4404341-4404045 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References