Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3537768..3538386 Replicon chromosome
Accession NZ_OW967975
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ150_RS17180 Protein ID WP_001291435.1
Coordinates 3538168..3538386 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ150_RS17175 Protein ID WP_000344800.1
Coordinates 3537768..3538142 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ150_RS17165 (3532857) 3532857..3534050 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ150_RS17170 (3534073) 3534073..3537222 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ150_RS17175 (3537768) 3537768..3538142 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ150_RS17180 (3538168) 3538168..3538386 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ150_RS17185 (3538558) 3538558..3539109 + 552 WP_000102564.1 maltose O-acetyltransferase -
LQ150_RS17190 (3539225) 3539225..3539695 + 471 WP_000136192.1 YlaC family protein -
LQ150_RS17195 (3539859) 3539859..3541409 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ150_RS17200 (3541451) 3541451..3541804 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ150_RS17210 (3542183) 3542183..3542494 + 312 WP_000409911.1 MGMT family protein -
LQ150_RS17215 (3542525) 3542525..3543097 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295914 WP_001291435.1 NZ_OW967975:3538168-3538386 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295914 WP_000344800.1 NZ_OW967975:3537768-3538142 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References