Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2499729..2500367 Replicon chromosome
Accession NZ_OW967975
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LQ150_RS12145 Protein ID WP_001447010.1
Coordinates 2500191..2500367 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ150_RS12140 Protein ID WP_001270286.1
Coordinates 2499729..2500145 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ150_RS12120 (2494881) 2494881..2495822 - 942 WP_001251304.1 ABC transporter permease -
LQ150_RS12125 (2495823) 2495823..2496836 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LQ150_RS12130 (2496854) 2496854..2497999 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LQ150_RS12135 (2498244) 2498244..2499650 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LQ150_RS12140 (2499729) 2499729..2500145 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ150_RS12145 (2500191) 2500191..2500367 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ150_RS12150 (2500589) 2500589..2500819 + 231 WP_000494244.1 YncJ family protein -
LQ150_RS12155 (2500911) 2500911..2502872 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ150_RS12160 (2502945) 2502945..2503481 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LQ150_RS12165 (2503573) 2503573..2504748 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T295913 WP_001447010.1 NZ_OW967975:c2500367-2500191 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT295913 WP_001270286.1 NZ_OW967975:c2500145-2499729 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References