Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4662817..4663742 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag LQ127_RS22860 Protein ID WP_014640052.1
Coordinates 4662817..4663203 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag LQ127_RS22865 Protein ID WP_024174200.1
Coordinates 4663233..4663742 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS22825 (4658382) 4658382..4658582 - 201 WP_021527487.1 YdaS family helix-turn-helix protein -
LQ127_RS22830 (4658673) 4658673..4659347 + 675 WP_021530636.1 LexA family transcriptional regulator -
LQ127_RS22835 (4660015) 4660015..4660377 + 363 WP_000135680.1 protein YfdP -
LQ127_RS22840 (4660443) 4660443..4661267 + 825 WP_023908886.1 DUF2303 family protein -
LQ127_RS22845 (4661456) 4661456..4662238 + 783 WP_023908887.1 hypothetical protein -
LQ127_RS22850 (4662275) 4662275..4662556 + 282 WP_001093916.1 pyocin activator PrtN family protein -
LQ127_RS22855 (4662604) 4662604..4662777 - 174 WP_023908888.1 hypothetical protein -
LQ127_RS22860 (4662817) 4662817..4663203 - 387 WP_014640052.1 hypothetical protein Toxin
LQ127_RS22865 (4663233) 4663233..4663742 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
LQ127_RS22870 (4664059) 4664059..4664163 - 105 Protein_4498 tRNA-dihydrouridine synthase -
LQ127_RS22875 (4664525) 4664525..4665529 - 1005 WP_022646425.1 DUF2713 family protein -
LQ127_RS22880 (4665847) 4665847..4666362 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
LQ127_RS22885 (4666404) 4666404..4666613 - 210 WP_001296638.1 CsbD family protein -
LQ127_RS22890 (4666729) 4666729..4668054 - 1326 WP_204166927.1 MATE family efflux transporter DinF -
LQ127_RS22895 (4668127) 4668127..4668735 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4620759..4668735 47976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T295897 WP_014640052.1 NZ_OW967966:c4663203-4662817 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT295897 WP_024174200.1 NZ_OW967966:c4663742-4663233 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References