Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4435926..4436521 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag LQ127_RS21685 Protein ID WP_000239581.1
Coordinates 4435926..4436276 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LQ127_RS21690 Protein ID WP_001223213.1
Coordinates 4436270..4436521 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS21665 (4431380) 4431380..4432402 - 1023 WP_001298067.1 ABC transporter permease -
LQ127_RS21670 (4432416) 4432416..4433918 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
LQ127_RS21675 (4434051) 4434051..4435007 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ127_RS21680 (4435317) 4435317..4435847 + 531 WP_000055075.1 inorganic diphosphatase -
LQ127_RS21685 (4435926) 4435926..4436276 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
LQ127_RS21690 (4436270) 4436270..4436521 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ127_RS21695 (4436733) 4436733..4437074 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ127_RS21700 (4437077) 4437077..4440856 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T295895 WP_000239581.1 NZ_OW967966:c4436276-4435926 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT295895 WP_001223213.1 NZ_OW967966:c4436521-4436270 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References