Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3352992..3353697 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LQ127_RS16430 Protein ID WP_000539521.1
Coordinates 3352992..3353378 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ127_RS16435 Protein ID WP_001280945.1
Coordinates 3353368..3353697 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS16410 (3348996) 3348996..3349622 + 627 WP_001295292.1 glutathione S-transferase GstB -
LQ127_RS16415 (3349619) 3349619..3350734 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
LQ127_RS16420 (3350845) 3350845..3351228 - 384 WP_000497137.1 biofilm formation regulator BssR -
LQ127_RS16425 (3351441) 3351441..3352766 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LQ127_RS16430 (3352992) 3352992..3353378 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ127_RS16435 (3353368) 3353368..3353697 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LQ127_RS16440 (3353767) 3353767..3354180 - 414 Protein_3242 GGDEF domain-containing protein -
LQ127_RS16445 (3354235) 3354235..3354932 + 698 WP_223216367.1 IS1 family transposase -
LQ127_RS16450 (3354939) 3354939..3355871 - 933 Protein_3244 GGDEF domain-containing protein -
LQ127_RS16455 (3355879) 3355879..3358227 - 2349 WP_022645413.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage mdf(A) - 3307199..3358227 51028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T295890 WP_000539521.1 NZ_OW967966:3352992-3353378 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT295890 WP_001280945.1 NZ_OW967966:3353368-3353697 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References