Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2639441..2640079 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LQ127_RS12840 Protein ID WP_000813794.1
Coordinates 2639903..2640079 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ127_RS12835 Protein ID WP_001270286.1
Coordinates 2639441..2639857 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS12815 (2634593) 2634593..2635534 - 942 WP_022645667.1 ABC transporter permease -
LQ127_RS12820 (2635535) 2635535..2636548 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
LQ127_RS12825 (2636566) 2636566..2637711 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
LQ127_RS12830 (2637956) 2637956..2639362 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
LQ127_RS12835 (2639441) 2639441..2639857 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ127_RS12840 (2639903) 2639903..2640079 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ127_RS12845 (2640301) 2640301..2640531 + 231 WP_000491567.1 DUF2554 family protein -
LQ127_RS12850 (2640623) 2640623..2642584 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ127_RS12855 (2642657) 2642657..2643193 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
LQ127_RS12860 (2643285) 2643285..2644457 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T295888 WP_000813794.1 NZ_OW967966:c2640079-2639903 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT295888 WP_001270286.1 NZ_OW967966:c2639857-2639441 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References