Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 223368..223980 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag LQ127_RS00995 Protein ID WP_000833473.1
Coordinates 223368..223553 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A1AGA0
Locus tag LQ127_RS01000 Protein ID WP_022646255.1
Coordinates 223570..223980 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS00980 (218834) 218834..220129 + 1296 WP_000985736.1 Fic family protein -
LQ127_RS00985 (220237) 220237..221775 + 1539 WP_000183976.1 aldehyde dehydrogenase AldB -
LQ127_RS00990 (221816) 221816..222895 - 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
LQ127_RS00995 (223368) 223368..223553 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ127_RS01000 (223570) 223570..223980 + 411 WP_022646255.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ127_RS01005 (224092) 224092..226071 - 1980 WP_022646254.1 glycoside hydrolase family 127 protein -
LQ127_RS01010 (226082) 226082..227482 - 1401 WP_001600688.1 MFS transporter -
LQ127_RS01015 (227708) 227708..228523 + 816 WP_022646253.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T295876 WP_000833473.1 NZ_OW967966:223368-223553 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15214.08 Da        Isoelectric Point: 4.4482

>AT295876 WP_022646255.1 NZ_OW967966:223570-223980 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALAAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AGA0

References