Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 94161..94804 Replicon plasmid P1
Accession NZ_OW967803
Organism Escherichia coli isolate 410

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag LQ147_RS23395 Protein ID WP_001044768.1
Coordinates 94388..94804 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag LQ147_RS23390 Protein ID WP_001261287.1
Coordinates 94161..94391 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ147_RS23380 (89339) 89339..90472 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
LQ147_RS23385 (90735) 90735..93854 - 3120 WP_023909028.1 hypothetical protein -
LQ147_RS23390 (94161) 94161..94391 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ147_RS23395 (94388) 94388..94804 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ147_RS23400 (94966) 94966..97104 - 2139 WP_000350635.1 AAA family ATPase -
LQ147_RS23405 (97569) 97569..98564 + 996 WP_000246636.1 hypothetical protein -
LQ147_RS23410 (98607) 98607..99500 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / sul1 / qacE / aadA2 / dfrA12 / blaNDM-5 / aadA5 / blaTEM-1B / aac(3)-IId / mph(A) / aph(6)-Id / aph(3'')-Ib / sul2 / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 - 1..109109 109109
- flank IS/Tn - - 99637..100140 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T295874 WP_001044768.1 NZ_OW967803:94388-94804 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT295874 WP_001261287.1 NZ_OW967803:94161-94391 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References