Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1123017..1123783 Replicon chromosome
Accession NC_021591
Organism Serratia plymuthica 4Rx13

Toxin (Protein)


Gene name ypjF Uniprot ID A0A318NVJ9
Locus tag SOD_RS05160 Protein ID WP_004949474.1
Coordinates 1123415..1123783 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U0NAH4
Locus tag SOD_RS05155 Protein ID WP_004949470.1
Coordinates 1123017..1123352 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SOD_RS05125 1119038..1119922 + 885 WP_020453717.1 hypothetical protein -
SOD_RS05130 1120754..1121011 + 258 WP_071824755.1 hypothetical protein -
SOD_RS05140 1121322..1121798 + 477 WP_004949461.1 hypothetical protein -
SOD_RS05145 1122040..1122489 + 450 WP_004949464.1 antirestriction protein -
SOD_RS05150 1122526..1123005 + 480 WP_041417310.1 DNA repair protein RadC -
SOD_RS05155 1123017..1123352 + 336 WP_004949470.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
SOD_RS05160 1123415..1123783 + 369 WP_004949474.1 TA system toxin CbtA family protein Toxin
SOD_RS05165 1123780..1124109 + 330 WP_020453718.1 hypothetical protein -
SOD_RS05170 1124560..1125801 + 1242 WP_004949476.1 IS110 family transposase -
SOD_RS25970 1125844..1126281 - 438 WP_020453720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1103407..1141119 37712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13620.63 Da        Isoelectric Point: 6.2145

>T29587 WP_004949474.1 NC_021591:1123415-1123783 [Serratia plymuthica 4Rx13]
MQTLPVTLKRAAQPCPSPVAVWQILLTYLLDQHYGLALNDTEFSDDAVIHEHIEAGISLADALNFTVEKFDLVRTDRRGF
SYLEQSPFVTAIDILRARRATGLMTRMGYQAITQAIQGGKQV

Download         Length: 369 bp

>T29587 NC_021591:1123415-1123783 [Serratia plymuthica 4Rx13]
ATGCAGACCTTACCTGTCACCCTTAAACGGGCGGCTCAGCCCTGCCCATCACCCGTTGCCGTCTGGCAGATCTTACTTAC
ATATCTATTGGATCAGCATTACGGCTTGGCGCTTAATGATACCGAGTTCAGTGATGACGCCGTGATCCACGAACATATTG
AAGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTGGAGAAGTTTGACCTGGTACGCACCGATCGCCGGGGTTTC
TCTTACCTGGAGCAATCCCCTTTCGTGACCGCCATCGATATCTTGCGGGCCCGCCGGGCCACCGGCCTGATGACCCGTAT
GGGTTACCAGGCCATCACGCAGGCTATTCAGGGAGGAAAGCAGGTATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12390.99 Da        Isoelectric Point: 6.6264

>AT29587 WP_004949470.1 NC_021591:1123017-1123352 [Serratia plymuthica 4Rx13]
MTSINTPAWGLKRNVTPQFGARLVQQGNHLHYLADRAGISGTFSEVQTRHLDEAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSYGYVYLAIYPTPQSTA

Download         Length: 336 bp

>AT29587 NC_021591:1123017-1123352 [Serratia plymuthica 4Rx13]
ATGACATCAATCAATACCCCAGCCTGGGGACTAAAACGCAACGTCACCCCACAATTTGGTGCTCGCCTCGTGCAGCAAGG
TAACCATCTGCACTATCTGGCTGATCGTGCTGGGATCAGCGGTACCTTCAGTGAGGTGCAAACTCGTCATTTGGATGAGG
CTTTTCCGCAGTTTATTAACCATCTCGAACTGATGCTGCTGTCCGGTGAACTCAATCCCCGCTATCAGCACTGCGTCACG
CTTTACTGCAATGGACTGACCTGCGAAGCCGACAGCCTGGGATCATACGGTTATGTGTATCTCGCCATTTATCCTACCCC
CCAATCCACTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318NVJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U0NAH4

References