Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4223581..4224078 Replicon chromosome
Accession NZ_OW967802
Organism Escherichia coli isolate 410

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ147_RS20395 Protein ID WP_001173343.1
Coordinates 4223581..4223754 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag LQ147_RS20400 Protein ID WP_001425728.1
Coordinates 4223782..4224078 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ147_RS20385 (4220251) 4220251..4221708 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
LQ147_RS20390 (4221945) 4221945..4223462 + 1518 WP_001295074.1 lysine--tRNA ligase -
LQ147_RS20395 (4223581) 4223581..4223754 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ147_RS20400 (4223782) 4223782..4224078 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ147_RS20405 (4224305) 4224305..4224577 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ147_RS20410 (4224589) 4224589..4224819 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
LQ147_RS20415 (4225000) 4225000..4226631 + 1632 WP_001216487.1 sensor histidine kinase -
LQ147_RS20420 (4226628) 4226628..4227347 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295868 WP_001173343.1 NZ_OW967802:c4223754-4223581 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT295868 WP_001425728.1 NZ_OW967802:c4224078-4223782 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References