Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3496739..3497357 Replicon chromosome
Accession NZ_OW967802
Organism Escherichia coli isolate 410

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ147_RS16915 Protein ID WP_001291435.1
Coordinates 3497139..3497357 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ147_RS16910 Protein ID WP_000344800.1
Coordinates 3496739..3497113 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ147_RS16900 (3491828) 3491828..3493021 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ147_RS16905 (3493044) 3493044..3496193 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ147_RS16910 (3496739) 3496739..3497113 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ147_RS16915 (3497139) 3497139..3497357 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ147_RS16920 (3497529) 3497529..3498080 + 552 WP_000102568.1 maltose O-acetyltransferase -
LQ147_RS16925 (3498196) 3498196..3498666 + 471 WP_000136192.1 YlaC family protein -
LQ147_RS16930 (3498830) 3498830..3500380 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ147_RS16935 (3500422) 3500422..3500775 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ147_RS16945 (3501154) 3501154..3501465 + 312 WP_000409911.1 MGMT family protein -
LQ147_RS16950 (3501496) 3501496..3502068 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295867 WP_001291435.1 NZ_OW967802:3497139-3497357 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295867 WP_000344800.1 NZ_OW967802:3496739-3497113 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References