Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 484371..485920 Replicon chromosome
Accession NC_021591
Organism Serratia plymuthica 4Rx13

Toxin (Protein)


Gene name hipA Uniprot ID A0A318P1Z0
Locus tag SOD_RS02250 Protein ID WP_004953059.1
Coordinates 484622..485920 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SOD_RS02245 Protein ID WP_004953056.1
Coordinates 484371..484619 (+) Length 83 a.a.

Genomic Context

SOD_RS02225SOD_RS02230SOD_RS02240SOD_RS02245SOD_RS02250SOD_RS24850SOD_RS02255SOD_RS02260SOD_RS02265SOD_RS02270SOD_RS25960
Location: 479708..480802 (1095 bp)
Type: Others
Protein ID: WP_004953048.1
Location: 480802..481872 (1071 bp)
Type: Others
Protein ID: WP_004953051.1
Location: 482443..483078 (636 bp)
Type: Others
Protein ID: WP_004953054.1
Location: 484371..484619 (249 bp)
Type: Antitoxin
Protein ID: WP_004953056.1
Location: 484622..485920 (1299 bp)
Type: Toxin
Protein ID: WP_004953059.1
Location: 483505..483962 (458 bp)
Type: Others
Protein ID: Protein_427
Location: 486183..487955 (1773 bp)
Type: Others
Protein ID: WP_004953065.1
Location: 487957..489030 (1074 bp)
Type: Others
Protein ID: WP_041416717.1
Location: 489430..490185 (756 bp)
Type: Others
Protein ID: WP_020453685.1
Location: 490377..490694 (318 bp)
Type: Others
Protein ID: WP_041416718.1
Location: 490749..490829 (81 bp)
Type: Others
Protein ID: Protein_434
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SOD_RS02225479708..480802+1095WP_004953048.1LPS export ABC transporter permease LptF-
SOD_RS02230480802..481872+1071WP_004953051.1LPS export ABC transporter permease LptG-
SOD_RS02240482443..483078+636WP_004953054.1carbonic anhydrase-
SOD_RS24850483505..483962-458Protein_427hypothetical protein-
SOD_RS02245484371..484619+249WP_004953056.1helix-turn-helix domain-containing proteinAntitoxin
SOD_RS02250484622..485920+1299WP_004953059.1type II toxin-antitoxin system HipA family toxinToxin
SOD_RS02255486183..487955-1773WP_004953065.1TIGR02391 family protein-
SOD_RS02260487957..489030-1074WP_041416717.1DNA cytosine methyltransferase-
SOD_RS02265489430..490185-756WP_020453685.1HNH endonuclease-
SOD_RS02270490377..490694-318WP_041416718.1hypothetical protein-
SOD_RS25960490749..490829-81Protein_434ash family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--465094..49089625802


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48346.39 Da        Isoelectric Point: 6.1359

>T29586 WP_004953059.1 NC_021591:484622-485920 [Serratia plymuthica 4Rx13]
MEKLRVALNGTLVGTLEKHAGGAMSFVYHEQWLTQAGVRAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQAHFR
TATKQPFDLLSSIGGDCVGAIQLYPEHADVASVRQVNAVPVSDEEIEQLLLGYREAPLGMEADIDDFRISLAGAQEKTAL
LWFGNQWCRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAKLARFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLTGSQQPLLDRDIFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMTELKAQTEQVI
ANVEAMLPDDFPRSVSDAIFAGVRRQAERLPG

Download         Length: 1299 bp

>T29586 NC_021591:484622-485920 [Serratia plymuthica 4Rx13]
ATGGAAAAGCTACGTGTGGCGCTGAATGGCACCCTTGTAGGGACGCTGGAAAAGCATGCGGGCGGCGCGATGTCGTTTGT
TTACCACGAACAGTGGCTGACACAAGCCGGCGTGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCGTTTCGCG
GTGACGTGGTGTATAACTTTTTCGACAACCTGCTGCCGGACAGCGAGCTTATTCGCAGCCGCCTACAGGCGCATTTTAGA
ACGGCAACCAAACAGCCTTTTGATCTGCTTTCCAGCATTGGCGGCGACTGCGTGGGTGCGATCCAGCTTTACCCTGAACA
TGCCGATGTGGCCTCGGTAAGGCAAGTGAACGCCGTGCCTGTGAGTGACGAAGAAATAGAGCAACTTCTGCTGGGGTACC
GCGAGGCGCCGTTAGGCATGGAAGCGGATATTGATGATTTCCGGATCTCTCTGGCGGGTGCGCAGGAAAAGACCGCGCTG
CTTTGGTTCGGCAATCAGTGGTGCCGGCCACAGGGGAGTACGCCAACCAGCCACATTATAAAACTGCCCATTGGGCATAT
TGCGCATAACAATCTGGATCTCAGCGAAAGCTGTGAGAATGAGTGGTTATGTTTGCGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTAAGTTGGCACGTTTTGGTGAGCAGAAGGTCCTGATTGTTGAGCGTTTTGACCGGCGTTGGGCGCGG
GATAACAGTTGGCTGATTCGTTTGCCGCAGGAGGATTTCTGCCAGGCGTTAGGCATTGCTCCTGCGCTGAAATATGAGGC
TGATGGCGGGCCCGGTATTGCGGCTGCGATGCAACTGCTAACGGGTTCTCAGCAGCCATTACTCGATCGAGACATCTTCT
TTAAAAGCCAAATCGTATTCTGGATGCTGGCGGCCATTGATGGGCATGCCAAAAACTTTAGCCTGTTCATTGAGCAGGAA
ACGGCCTATCGAATGACTCCGCTTTACGATGTGCTCTCGGGTTACCCATTTATGCATGCCCGTGGCATCGCGCCGCAGAA
AGCCAAAATGGCCATGGCCGTATTGGGGCAGAGTCGCCATTACCGCTGGAGCCAGATCTTGCCTCGGCACTTTATCTCTA
CCGCGAGAGCCGTAGGGTATTCTGAAGAGAAAACGCTGCAGGTGATGACTGAGCTAAAAGCGCAAACGGAGCAGGTGATC
GCCAATGTGGAAGCAATGCTGCCGGACGATTTCCCCCGTTCTGTGAGTGATGCGATTTTTGCCGGGGTTCGGCGGCAGGC
TGAGAGGTTGCCGGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9263.60 Da        Isoelectric Point: 10.4887

>AT29586 WP_004953056.1 NC_021591:484371-484619 [Serratia plymuthica 4Rx13]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Download         Length: 249 bp

>AT29586 NC_021591:484371-484619 [Serratia plymuthica 4Rx13]
ATGAAAATCACCTCGGCAAAGATGTTGGCGCATGCGCTACGCAATGAACGTAAAAAGCGTAACCAAAGCCAAAGTAAAAC
TGCTGACAGCATTGGGTTAAAGCAGGCCACGGTTTCCGCGTTTGAAAACAACCCGGACGGCACGCGGCTGGAAACGTTAT
TCAAACTGCTTGCTGCGCTGGACTTAGAGCTACAAGTGACCCCGCGCGGTAAGCCGGTCGATCCCAAAACCTGGGATCAG
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A318P1Z0

Antitoxin

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Source
ID
Structure
No matching records found

References