Detailed information of TA system TA029586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 484371..485920
• Replicon: chromosome
• Accession: NC_021591
• Organism: Serratia plymuthica 4Rx13

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A318P1Z0
• Locus tag: SOD_RS02250
• Protein ID: WP_004953059.1
• Coordinates: 484622..485920 (+)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SOD_RS02245
• Protein ID: WP_004953056.1
• Coordinates: 484371..484619 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SOD_RS02225	479708..480802	+	1095	WP_004953048.1	LPS export ABC transporter permease LptF	-
SOD_RS02230	480802..481872	+	1071	WP_004953051.1	LPS export ABC transporter permease LptG	-
SOD_RS02240	482443..483078	+	636	WP_004953054.1	carbonic anhydrase	-
SOD_RS24850	483505..483962	-	458	Protein_427	hypothetical protein	-
SOD_RS02245	484371..484619	+	249	WP_004953056.1	helix-turn-helix domain-containing protein	Antitoxin
SOD_RS02250	484622..485920	+	1299	WP_004953059.1	type II toxin-antitoxin system HipA family toxin	Toxin
SOD_RS02255	486183..487955	-	1773	WP_004953065.1	TIGR02391 family protein	-
SOD_RS02260	487957..489030	-	1074	WP_041416717.1	DNA cytosine methyltransferase	-
SOD_RS02265	489430..490185	-	756	WP_020453685.1	HNH endonuclease	-
SOD_RS02270	490377..490694	-	318	WP_041416718.1	hypothetical protein	-
SOD_RS25960	490749..490829	-	81	Protein_434	ash family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	465094..490896	25802

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48346.39 Da
• Isoelectric Point: 6.1359

>T29586 WP_004953059.1 NC_021591:484622-485920 [Serratia plymuthica 4Rx13]
MEKLRVALNGTLVGTLEKHAGGAMSFVYHEQWLTQAGVRAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQAHFR
TATKQPFDLLSSIGGDCVGAIQLYPEHADVASVRQVNAVPVSDEEIEQLLLGYREAPLGMEADIDDFRISLAGAQEKTAL
LWFGNQWCRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAKLARFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLTGSQQPLLDRDIFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMTELKAQTEQVI
ANVEAMLPDDFPRSVSDAIFAGVRRQAERLPG

Nucleotide

• Length: 1299 bp

>T29586 NC_021591:484622-485920 [Serratia plymuthica 4Rx13]
ATGGAAAAGCTACGTGTGGCGCTGAATGGCACCCTTGTAGGGACGCTGGAAAAGCATGCGGGCGGCGCGATGTCGTTTGT
TTACCACGAACAGTGGCTGACACAAGCCGGCGTGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCGTTTCGCG
GTGACGTGGTGTATAACTTTTTCGACAACCTGCTGCCGGACAGCGAGCTTATTCGCAGCCGCCTACAGGCGCATTTTAGA
ACGGCAACCAAACAGCCTTTTGATCTGCTTTCCAGCATTGGCGGCGACTGCGTGGGTGCGATCCAGCTTTACCCTGAACA
TGCCGATGTGGCCTCGGTAAGGCAAGTGAACGCCGTGCCTGTGAGTGACGAAGAAATAGAGCAACTTCTGCTGGGGTACC
GCGAGGCGCCGTTAGGCATGGAAGCGGATATTGATGATTTCCGGATCTCTCTGGCGGGTGCGCAGGAAAAGACCGCGCTG
CTTTGGTTCGGCAATCAGTGGTGCCGGCCACAGGGGAGTACGCCAACCAGCCACATTATAAAACTGCCCATTGGGCATAT
TGCGCATAACAATCTGGATCTCAGCGAAAGCTGTGAGAATGAGTGGTTATGTTTGCGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTAAGTTGGCACGTTTTGGTGAGCAGAAGGTCCTGATTGTTGAGCGTTTTGACCGGCGTTGGGCGCGG
GATAACAGTTGGCTGATTCGTTTGCCGCAGGAGGATTTCTGCCAGGCGTTAGGCATTGCTCCTGCGCTGAAATATGAGGC
TGATGGCGGGCCCGGTATTGCGGCTGCGATGCAACTGCTAACGGGTTCTCAGCAGCCATTACTCGATCGAGACATCTTCT
TTAAAAGCCAAATCGTATTCTGGATGCTGGCGGCCATTGATGGGCATGCCAAAAACTTTAGCCTGTTCATTGAGCAGGAA
ACGGCCTATCGAATGACTCCGCTTTACGATGTGCTCTCGGGTTACCCATTTATGCATGCCCGTGGCATCGCGCCGCAGAA
AGCCAAAATGGCCATGGCCGTATTGGGGCAGAGTCGCCATTACCGCTGGAGCCAGATCTTGCCTCGGCACTTTATCTCTA
CCGCGAGAGCCGTAGGGTATTCTGAAGAGAAAACGCTGCAGGTGATGACTGAGCTAAAAGCGCAAACGGAGCAGGTGATC
GCCAATGTGGAAGCAATGCTGCCGGACGATTTCCCCCGTTCTGTGAGTGATGCGATTTTTGCCGGGGTTCGGCGGCAGGC
TGAGAGGTTGCCGGGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9263.60 Da
• Isoelectric Point: 10.4887

>AT29586 WP_004953056.1 NC_021591:484371-484619 [Serratia plymuthica 4Rx13]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT29586 NC_021591:484371-484619 [Serratia plymuthica 4Rx13]
ATGAAAATCACCTCGGCAAAGATGTTGGCGCATGCGCTACGCAATGAACGTAAAAAGCGTAACCAAAGCCAAAGTAAAAC
TGCTGACAGCATTGGGTTAAAGCAGGCCACGGTTTCCGCGTTTGAAAACAACCCGGACGGCACGCGGCTGGAAACGTTAT
TCAAACTGCTTGCTGCGCTGGACTTAGAGCTACAAGTGACCCCGCGCGGTAAGCCGGTCGATCCCAAAACCTGGGATCAG
GAGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A318P1Z0