Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1345320..1345945 Replicon chromosome
Accession NZ_OW967802
Organism Escherichia coli isolate 410

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ147_RS06545 Protein ID WP_000911330.1
Coordinates 1345547..1345945 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LQ147_RS06540 Protein ID WP_000450524.1
Coordinates 1345320..1345547 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ147_RS06515 (1341123) 1341123..1341593 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LQ147_RS06520 (1341593) 1341593..1342165 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LQ147_RS06525 (1342311) 1342311..1343189 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LQ147_RS06530 (1343206) 1343206..1344240 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LQ147_RS06535 (1344453) 1344453..1345166 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LQ147_RS06540 (1345320) 1345320..1345547 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LQ147_RS06545 (1345547) 1345547..1345945 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ147_RS06550 (1346092) 1346092..1346955 + 864 WP_001267507.1 neutral zinc metallopeptidase -
LQ147_RS06555 (1346970) 1346970..1348985 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
LQ147_RS06560 (1349059) 1349059..1349400 + 342 Protein_1286 esterase -
LQ147_RS06565 (1349482) 1349482..1350228 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T295858 WP_000911330.1 NZ_OW967802:1345547-1345945 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT295858 WP_000450524.1 NZ_OW967802:1345320-1345547 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References