Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 903565..904219 Replicon chromosome
Accession NZ_OW967802
Organism Escherichia coli isolate 410

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LQ147_RS04435 Protein ID WP_000244777.1
Coordinates 903812..904219 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ147_RS04430 Protein ID WP_000354046.1
Coordinates 903565..903831 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ147_RS04405 (898853) 898853..899596 + 744 Protein_868 SDR family oxidoreductase -
LQ147_RS04410 (899653) 899653..901086 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
LQ147_RS04415 (901131) 901131..901442 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
LQ147_RS04420 (901606) 901606..902265 + 660 WP_000250274.1 hemolysin III family protein -
LQ147_RS04425 (902342) 902342..903322 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LQ147_RS04430 (903565) 903565..903831 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ147_RS04435 (903812) 903812..904219 + 408 WP_000244777.1 protein YgfX Toxin
LQ147_RS04440 (904259) 904259..904780 - 522 WP_001055874.1 flavodoxin FldB -
LQ147_RS04445 (904892) 904892..905788 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ147_RS04450 (905813) 905813..906523 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ147_RS04455 (906529) 906529..908262 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T295855 WP_000244777.1 NZ_OW967802:903812-904219 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295855 WP_000354046.1 NZ_OW967802:903565-903831 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References