Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 93936..94561 Replicon plasmid P1
Accession NZ_OW967796
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ148_RS23275 Protein ID WP_000911317.1
Coordinates 94163..94561 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag LQ148_RS23270 Protein ID WP_000450532.1
Coordinates 93936..94163 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS23270 (93936) 93936..94163 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
LQ148_RS23275 (94163) 94163..94561 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ148_RS23280 (94570) 94570..96723 - 2154 WP_001523486.1 type IV conjugative transfer system coupling protein TraD -
LQ148_RS23285 (96976) 96976..97707 - 732 WP_001523488.1 conjugal transfer complement resistance protein TraT -
LQ148_RS23290 (97756) 97756..98241 - 486 WP_230158930.1 surface exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - papH / papC / hlyB / iroB / iroC / iroD / iroE / iroN / papC / papH 1..148717 148717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T295846 WP_000911317.1 NZ_OW967796:94163-94561 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT295846 WP_000450532.1 NZ_OW967796:93936-94163 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References