Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4201243..4201740 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ148_RS20395 Protein ID WP_001173343.1
Coordinates 4201243..4201416 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag LQ148_RS20400 Protein ID WP_001312331.1
Coordinates 4201444..4201740 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS20385 (4197913) 4197913..4199370 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
LQ148_RS20390 (4199607) 4199607..4201124 + 1518 WP_000003806.1 lysine--tRNA ligase -
LQ148_RS20395 (4201243) 4201243..4201416 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ148_RS20400 (4201444) 4201444..4201740 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ148_RS20405 (4201968) 4201968..4202240 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ148_RS20410 (4202454) 4202454..4206383 - 3930 WP_033556233.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4201243..4217487 16244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295842 WP_001173343.1 NZ_OW967795:c4201416-4201243 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT295842 WP_001312331.1 NZ_OW967795:c4201740-4201444 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References