Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3340877..3341495 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ148_RS16145 Protein ID WP_001291435.1
Coordinates 3341277..3341495 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ148_RS16140 Protein ID WP_000344800.1
Coordinates 3340877..3341251 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS16130 (3335967) 3335967..3337160 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ148_RS16135 (3337183) 3337183..3340332 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
LQ148_RS16140 (3340877) 3340877..3341251 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ148_RS16145 (3341277) 3341277..3341495 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ148_RS16150 (3341668) 3341668..3342219 + 552 WP_000102539.1 maltose O-acetyltransferase -
LQ148_RS16155 (3342335) 3342335..3342805 + 471 WP_000136192.1 YlaC family protein -
LQ148_RS16160 (3342969) 3342969..3344519 + 1551 WP_022296625.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ148_RS16165 (3344561) 3344561..3344914 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ148_RS16175 (3345293) 3345293..3345604 + 312 WP_000409908.1 MGMT family protein -
LQ148_RS16180 (3345635) 3345635..3346207 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295838 WP_001291435.1 NZ_OW967795:3341277-3341495 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295838 WP_000344800.1 NZ_OW967795:3340877-3341251 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References