Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2327630..2329218 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQ148_RS11170 Protein ID WP_001524713.1
Coordinates 2327896..2329218 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag LQ148_RS11165 Protein ID WP_001296076.1
Coordinates 2327630..2327896 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS11150 (2323998) 2323998..2325449 + 1452 WP_000854638.1 tagaturonate reductase -
LQ148_RS11155 (2325646) 2325646..2326560 + 915 WP_001385356.1 bestrophin family protein -
LQ148_RS11160 (2326564) 2326564..2327322 - 759 WP_001524715.1 trans-aconitate 2-methyltransferase -
LQ148_RS11165 (2327630) 2327630..2327896 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQ148_RS11170 (2327896) 2327896..2329218 + 1323 WP_001524713.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LQ148_RS11175 (2330117) 2330117..2330680 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
LQ148_RS11180 (2331042) 2331042..2331752 + 711 WP_001195177.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49341.97 Da        Isoelectric Point: 7.7906

>T295835 WP_001524713.1 NZ_OW967795:2327896-2329218 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLVPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT295835 WP_001296076.1 NZ_OW967795:2327630-2327896 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References